Publications
Selected Publications
35. J.M. Suski, N. Ratnayeke, M. Braun, T. Zhang, V. Strmiska, W. Michowski, G. Can, A. Simoneau, K. Snioch, M. Cup, C.M. Sullivan, X. Wu, J. Nowacka, T.B. Branigan, L.R. Pack, J.A. DeCaprio, Y. Geng, L. Zou, S.P. Gygi, J.C. Walter, T. Meyer, P. Sicinski, CDC7-independent G1/S transition revealed by targeted protein degradation. Nature, 2022. 605(7909):357-365.
34. A. Fassl, Y. Geng, P. Sicinski, CDK4 and CDK6 kinases: From basic science to cancer therapy. Science, 2022. 375(6577):eabc1495. (Get free access)
33. C. Chu, Y. Geng, Y. Zhou, P. Sicinski, Cyclin E in normal physiology and disease states. Trends Cell Biol, 2021. 31(9):732-746.
32. J.M. Suski, M. Braun, V. Strmiska, P. Sicinski, Targeting cell-cycle machinery in cancer. Cancer Cell, 2021. 14;39(6):759-778.
31. Y. Gao, N.T. Nihira, X. Bu, C. Chu, J. Zhang, A. Kolodziejczyk, Y. Fan, N.T. Chan, L. Ma, J. Liu, D. Wang, X. Dai, H. Liu, M. Ono, A. Nakanishi, H. Inuzuka, B.J. North, Y.H. Huang, S. Sharma, Y. Geng, W. Xu, X.S. Liu, L. Li, Y. Miki, P. Sicinski, G.J. Freeman and W. Wei, Acetylation-dependent regulation of PD-L1 nuclear translocation dictates the efficacy of anti-PD-1 immunotherapy. Nat Cell Biol, 2020. 22(9):1064-1075.
30. A. Fassl, C. Brian, M. Abu-Remaileh, I. Stukan, D. Butter, P. Stepien, A.S. Feit, J. Bergholz, W. Michowski, T. Otto, Q. Sheng, A. Loo, W. Michael, R. Tiedt, C. DeAngelis, R. Schiff, B. Jiang, B. Juvanovic, K. Nowak, M. Ericsson, M. Cameron, N. Gray, D. Dillon, J.J. Zhao, D.M. Sabatini, R. Jeselsohn, M. Brown, K. Polyak and P. Sicinski, Increased lysosomal biomass is responsible for the resistance of triple-negative breast cancers to CDK4/6 inhibition. Sci Adv, 2020. 17;6(25):eabb2210.
29. W. Michowski, J.M. Chick, C. Chu, A. Kolodziejczyk, Y. Wang, J.M. Suski, B. Abraham, L. Anders, D. Day, L.M. Dunkl, M.L.C. Man, T. Zhang, P. Laphanuwat, N.A. Bacon, L. Liu, A. Fassl, S. Sharma, T. Otto, E. Jecrois, R. Han, K.E. Sweeney, S. Marro, M. Wernig, Y. Geng, A. Moses, C. Li, S.P. Gygi, R.A. Young and P. Sicinski, Cdk1 controls global epigenetic landscape in embryonic stem cells. Mol Cell, 2020. 78(3): p. 459-476.
28. S. Sharma, T. Zhang, W. Michowski, V.W. Rebecca, M. Xiao, R. Ferretti, J.M. Suski, R.T. Bronson, J.A. Paulo, D. Frederick, A. Fassl, G.M. Boland, Y. Geng, J.A. Lees, R.H. Medema, M. Herlyn, S.P. Gygi and P. Sicinski, Targeting the cyclin-dependent kinase 5 in metastatic melanoma. Proc Natl Acad Sci U S A, 2020. 117(14): p. 8001-8012.
27. L. Liu, W. Michowski, A. Kolodziejczyk and P. Sicinski, The cell cycle in stem cell proliferation, pluripotency and differentiation. Nat Cell Biol, 2019. 21(9): p. 1060-1067.
26. J. Zhang, X. Bu, H. Wang, Y. Zhu, Y. Geng, N.T. Nihira, Y. Tan, Y. Ci, F. Wu, X. Dai, J. Guo, Y.H. Huang, C. Fan, S. Ren, Y. Sun, G.J. Freeman, P. Sicinski, and W. Wei, Cyclin D-CDK4 kinase destabilizes PD-L1 via cullin 3-SPOP to control cancer immune surveillance. Nature, 2018. 553(7686): p. 91-95.
25. Y. Geng, W. Michowski, J.M. Chick, Y.E. Wang, M.E. Jecrois, K.E. Sweeney, L. Liu, R.C. Han, N. Ke, A. Zagozdzon, E. Sicinska, R.T. Bronson, S.P. Gygi, and P. Sicinski, Kinase-independent function of E-type cyclins in liver cancer. Proc Natl Acad Sci U S A, 2018. 115(5): p. 1015-1020.
24. T. Otto, S.V. Candido, M.S. Pilarz, E. Sicinska, R.T. Bronson, M. Bowden, I.A. Lachowicz, K. Mulry, A. Fassl, R.C. Han, E.S. Jecrois, and P. Sicinski, Cell cycle-targeting microRNAs promote differentiation by enforcing cell-cycle exit. Proc Natl Acad Sci U S A, 2017. 114(40): p. 10660-10665.
23. H. Wang, B.N. Nicolay, J.M. Chick, X. Gao, Y. Geng, H. Ren, H. Gao, G. Yang, J.A. Williams, J.M. Suski, M.A. Keibler, E. Sicinska, U. Gerdemann, W.N. Haining, T.M. Roberts, K. Polyak, S.P. Gygi, N.J. Dyson, and P. Sicinski, The metabolic function of cyclin D3-CDK6 kinase in cancer cell survival. Nature, 2017. 546(7658): p. 426-430.
22. P. Hydbring, Y. Wang, A. Fassl, X. Li, V. Matia, T. Otto, Y.J. Choi, K.E. Sweeney, J.M. Suski, H. Yin, R.L. Bogorad, S. Goel, H. Yuzugullu, K.J. Kauffman, J. Yang, C. Jin, Y. Li, D. Floris, R. Swanson, K. Ng, E. Sicinska, L. Anders, J.J. Zhao, K. Polyak, D.G. Anderson, C. Li, and P. Sicinski, Cell-Cycle-Targeting MicroRNAs as Therapeutic Tools against Refractory Cancers. Cancer Cell, 2017. 31(4): p. 576-590 e8.
21. L. Liu, W. Michowski, H. Inuzuka, K. Shimizu, N.T. Nihira, J.M. Chick, N. Li, Y. Geng, A.Y. Meng, A. Ordureau, A. Kolodziejczyk, K.L. Ligon, R.T. Bronson, K. Polyak, J.W. Harper, S.P. Gygi, W. Wei, and P. Sicinski, G1 cyclins link proliferation, pluripotency and differentiation of embryonic stem cells. Nat Cell Biol, 2017. 19(3): p. 177-188.
20. T. Otto and P. Sicinski, Cell cycle proteins as promising targets in cancer therapy. Nat Rev Cancer, 2017. 17(2): p. 93-115.
19. P. Hydbring, M. Malumbres, and P. Sicinski, Non-canonical functions of cell cycle cyclins and cyclin-dependent kinases. Nat Rev Mol Cell Biol, 2016. 17(5): p. 280-292.
18. N. Li, A. Fassl, J. Chick, H. Inuzuka, X. Li, M.R. Mansour, L. Liu, H. Wang, B. King, S. Shaik, A. Gutierrez, A. Ordureau, T. Otto, T. Kreslavsky, L. Baitsch, L. Bury, C.A. Meyer, N. Ke, K.A. Mulry, M.J. Kluk, M. Roy, S. Kim, X. Zhang, Y. Geng, A. Zagozdzon, S. Jenkinson, R.E. Gale, D.C. Linch, J.J. Zhao, C.G. Mullighan, J.W. Harper, J.C. Aster, I. Aifantis, H. von Boehmer, S.P. Gygi, W. Wei, A.T. Look, and P. Sicinski, Cyclin C is a haploinsufficient tumour suppressor. Nat Cell Biol, 2014. 16(11): p. 1080-1091.
17. Y.J. Choi, B. Saez, L. Anders, P. Hydbring, J. Stefano, N.A. Bacon, C. Cook, I. Kalaszczynska, S. Signoretti, R.A. Young, D.T. Scadden, and P. Sicinski, D-cyclins repress apoptosis in hematopoietic cells by controlling death receptor Fas and its ligand FasL. Dev Cell, 2014. 30(3): p. 255-267.
16. Y.J. Choi, X. Li, P. Hydbring, T. Sanda, J. Stefano, A.L. Christie, S. Signoretti, A.T. Look, A.L. Kung, H. von Boehmer, and P. Sicinski, The requirement for cyclin D function in tumor maintenance. Cancer Cell, 2012. 22(4): p. 438-451.
15. L. Anders, N. Ke, P. Hydbring, Y.J. Choi, H.R. Widlund, J.M. Chick, H. Zhai, M. Vidal, S.P. Gygi, P. Braun, and P. Sicinski, A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells. Cancer Cell, 2011. 20(5): p. 620-634.
14. J. Odajima, Z.P. Wills, Y.M. Ndassa, M. Terunuma, K. Kretschmannova, T.Z. Deeb, Y. Geng, S. Gawrzak, I.M. Quadros, J. Newman, M. Das, M.E. Jecrois, Q. Yu, N. Li, F. Bienvenu, S.J. Moss, M.E. Greenberg, J.A. Marto, and P. Sicinski, Cyclin E constrains Cdk5 activity to regulate synaptic plasticity and memory formation. Dev Cell, 2011. 21(4): p. 655-668.
13. S. Jirawatnotai, Y. Hu, W. Michowski, J.E. Elias, L. Becks, F. Bienvenu, A. Zagozdzon, T. Goswami, Y.E. Wang, A.B. Clark, T.A. Kunkel, T. van Harn, B. Xia, M. Correll, J. Quackenbush, D.M. Livingston, S.P. Gygi, and P. Sicinski, A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers. Nature, 2011. 474(7350): p. 230-234.
12. F. Bienvenu, S. Jirawatnotai, J.E. Elias, C.A. Meyer, K. Mizeracka, A. Marson, G.M. Frampton, M.F. Cole, D.T. Odom, J. Odajima, Y. Geng, A. Zagozdzon, M. Jecrois, R.A. Young, X.S. Liu, C.L. Cepko, S.P. Gygi, and P. Sicinski, Transcriptional role of cyclin D1 in development revealed by a genetic-proteomic screen. Nature, 2010. 463(7279): p. 374-378.
11. I. Kalaszczynska, Y. Geng, T. Iino, S. Mizuno, Y. Choi, I. Kondratiuk, D.P. Silver, D.J. Wolgemuth, K. Akashi, and P. Sicinski, Cyclin A is redundant in fibroblasts but essential in hematopoietic and embryonic stem cells. Cell, 2009. 138(2): p. 352-365.
10. Y. Geng, Y.M. Lee, M. Welcker, J. Swanger, A. Zagozdzon, J.D. Winer, J.M. Roberts, P. Kaldis, B.E. Clurman, and P. Sicinski, Kinase-independent function of cyclin E. Mol Cell, 2007. 25(1): p. 127-139.
9. Q. Yu, E. Sicinska, Y. Geng, M. Ahnstrom, A. Zagozdzon, Y. Kong, H. Gardner, H. Kiyokawa, L.N. Harris, O. Stal, and P. Sicinski, Requirement for CDK4 kinase function in breast cancer. Cancer Cell, 2006. 9(1): p. 23-32.
8. K. Kozar, M.A. Ciemerych, V.I. Rebel, H. Shigematsu, A. Zagozdzon, E. Sicinska, Y. Geng, Q. Yu, S. Bhattacharya, R.T. Bronson, K. Akashi, and P. Sicinski, Mouse development and cell proliferation in the absence of D-cyclins. Cell, 2004. 118(4): p. 477-491.
7. E. Sicinska, I. Aifantis, L. Le Cam, W. Swat, C. Borowski, Q. Yu, A.A. Ferrando, S.D. Levin, Y. Geng, H. von Boehmer, and P. Sicinski, Requirement for cyclin D3 in lymphocyte development and T cell leukemias. Cancer Cell, 2003. 4(6): p. 451-461.
6. Y. Geng, Q. Yu, E. Sicinska, M. Das, J.E. Schneider, S. Bhattacharya, W.M. Rideout, R.T. Bronson, H. Gardner, and P. Sicinski, Cyclin E ablation in the mouse. Cell, 2003. 114(4): p. 431-443.
5. M.A. Ciemerych, A.M. Kenney, E. Sicinska, I. Kalaszczynska, R.T. Bronson, D.H. Rowitch, H. Gardner, and P. Sicinski, Development of mice expressing a single D-type cyclin. Genes Dev, 2002. 16(24): p. 3277-3289.
4. Y. Geng, Q. Yu, W. Whoriskey, F. Dick, K.Y. Tsai, H.L. Ford, D.K. Biswas, A.B. Pardee, B. Amati, T. Jacks, A. Richardson, N. Dyson, and P. Sicinski, Expression of cyclins E1 and E2 during mouse development and in neoplasia. Proc Natl Acad Sci U S A, 2001. 98(23): p. 13138-13143.
3. Q. Yu, Y. Geng, and P. Sicinski, Specific protection against breast cancers by cyclin D1 ablation. Nature, 2001. 411(6841): p. 1017-1021.
2. Y. Geng, Q. Yu, E. Sicinska, M. Das, R.T. Bronson, and P. Sicinski, Deletion of the p27Kip1 gene restores normal development in cyclin D1-deficient mice. Proc Natl Acad Sci U S A, 2001. 98(1): p. 194-199.
1. Y. Geng, W. Whoriskey, M.Y. Park, R.T. Bronson, R.H. Medema, T. Li, R.A. Weinberg, and P. Sicinski, Rescue of cyclin D1 deficiency by knockin cyclin E. Cell, 1999. 97(6): p. 767-777.
34. A. Fassl, Y. Geng, P. Sicinski, CDK4 and CDK6 kinases: From basic science to cancer therapy. Science, 2022. 375(6577):eabc1495. (Get free access)
33. C. Chu, Y. Geng, Y. Zhou, P. Sicinski, Cyclin E in normal physiology and disease states. Trends Cell Biol, 2021. 31(9):732-746.
32. J.M. Suski, M. Braun, V. Strmiska, P. Sicinski, Targeting cell-cycle machinery in cancer. Cancer Cell, 2021. 14;39(6):759-778.
31. Y. Gao, N.T. Nihira, X. Bu, C. Chu, J. Zhang, A. Kolodziejczyk, Y. Fan, N.T. Chan, L. Ma, J. Liu, D. Wang, X. Dai, H. Liu, M. Ono, A. Nakanishi, H. Inuzuka, B.J. North, Y.H. Huang, S. Sharma, Y. Geng, W. Xu, X.S. Liu, L. Li, Y. Miki, P. Sicinski, G.J. Freeman and W. Wei, Acetylation-dependent regulation of PD-L1 nuclear translocation dictates the efficacy of anti-PD-1 immunotherapy. Nat Cell Biol, 2020. 22(9):1064-1075.
30. A. Fassl, C. Brian, M. Abu-Remaileh, I. Stukan, D. Butter, P. Stepien, A.S. Feit, J. Bergholz, W. Michowski, T. Otto, Q. Sheng, A. Loo, W. Michael, R. Tiedt, C. DeAngelis, R. Schiff, B. Jiang, B. Juvanovic, K. Nowak, M. Ericsson, M. Cameron, N. Gray, D. Dillon, J.J. Zhao, D.M. Sabatini, R. Jeselsohn, M. Brown, K. Polyak and P. Sicinski, Increased lysosomal biomass is responsible for the resistance of triple-negative breast cancers to CDK4/6 inhibition. Sci Adv, 2020. 17;6(25):eabb2210.
29. W. Michowski, J.M. Chick, C. Chu, A. Kolodziejczyk, Y. Wang, J.M. Suski, B. Abraham, L. Anders, D. Day, L.M. Dunkl, M.L.C. Man, T. Zhang, P. Laphanuwat, N.A. Bacon, L. Liu, A. Fassl, S. Sharma, T. Otto, E. Jecrois, R. Han, K.E. Sweeney, S. Marro, M. Wernig, Y. Geng, A. Moses, C. Li, S.P. Gygi, R.A. Young and P. Sicinski, Cdk1 controls global epigenetic landscape in embryonic stem cells. Mol Cell, 2020. 78(3): p. 459-476.
28. S. Sharma, T. Zhang, W. Michowski, V.W. Rebecca, M. Xiao, R. Ferretti, J.M. Suski, R.T. Bronson, J.A. Paulo, D. Frederick, A. Fassl, G.M. Boland, Y. Geng, J.A. Lees, R.H. Medema, M. Herlyn, S.P. Gygi and P. Sicinski, Targeting the cyclin-dependent kinase 5 in metastatic melanoma. Proc Natl Acad Sci U S A, 2020. 117(14): p. 8001-8012.
27. L. Liu, W. Michowski, A. Kolodziejczyk and P. Sicinski, The cell cycle in stem cell proliferation, pluripotency and differentiation. Nat Cell Biol, 2019. 21(9): p. 1060-1067.
26. J. Zhang, X. Bu, H. Wang, Y. Zhu, Y. Geng, N.T. Nihira, Y. Tan, Y. Ci, F. Wu, X. Dai, J. Guo, Y.H. Huang, C. Fan, S. Ren, Y. Sun, G.J. Freeman, P. Sicinski, and W. Wei, Cyclin D-CDK4 kinase destabilizes PD-L1 via cullin 3-SPOP to control cancer immune surveillance. Nature, 2018. 553(7686): p. 91-95.
25. Y. Geng, W. Michowski, J.M. Chick, Y.E. Wang, M.E. Jecrois, K.E. Sweeney, L. Liu, R.C. Han, N. Ke, A. Zagozdzon, E. Sicinska, R.T. Bronson, S.P. Gygi, and P. Sicinski, Kinase-independent function of E-type cyclins in liver cancer. Proc Natl Acad Sci U S A, 2018. 115(5): p. 1015-1020.
24. T. Otto, S.V. Candido, M.S. Pilarz, E. Sicinska, R.T. Bronson, M. Bowden, I.A. Lachowicz, K. Mulry, A. Fassl, R.C. Han, E.S. Jecrois, and P. Sicinski, Cell cycle-targeting microRNAs promote differentiation by enforcing cell-cycle exit. Proc Natl Acad Sci U S A, 2017. 114(40): p. 10660-10665.
23. H. Wang, B.N. Nicolay, J.M. Chick, X. Gao, Y. Geng, H. Ren, H. Gao, G. Yang, J.A. Williams, J.M. Suski, M.A. Keibler, E. Sicinska, U. Gerdemann, W.N. Haining, T.M. Roberts, K. Polyak, S.P. Gygi, N.J. Dyson, and P. Sicinski, The metabolic function of cyclin D3-CDK6 kinase in cancer cell survival. Nature, 2017. 546(7658): p. 426-430.
22. P. Hydbring, Y. Wang, A. Fassl, X. Li, V. Matia, T. Otto, Y.J. Choi, K.E. Sweeney, J.M. Suski, H. Yin, R.L. Bogorad, S. Goel, H. Yuzugullu, K.J. Kauffman, J. Yang, C. Jin, Y. Li, D. Floris, R. Swanson, K. Ng, E. Sicinska, L. Anders, J.J. Zhao, K. Polyak, D.G. Anderson, C. Li, and P. Sicinski, Cell-Cycle-Targeting MicroRNAs as Therapeutic Tools against Refractory Cancers. Cancer Cell, 2017. 31(4): p. 576-590 e8.
21. L. Liu, W. Michowski, H. Inuzuka, K. Shimizu, N.T. Nihira, J.M. Chick, N. Li, Y. Geng, A.Y. Meng, A. Ordureau, A. Kolodziejczyk, K.L. Ligon, R.T. Bronson, K. Polyak, J.W. Harper, S.P. Gygi, W. Wei, and P. Sicinski, G1 cyclins link proliferation, pluripotency and differentiation of embryonic stem cells. Nat Cell Biol, 2017. 19(3): p. 177-188.
20. T. Otto and P. Sicinski, Cell cycle proteins as promising targets in cancer therapy. Nat Rev Cancer, 2017. 17(2): p. 93-115.
19. P. Hydbring, M. Malumbres, and P. Sicinski, Non-canonical functions of cell cycle cyclins and cyclin-dependent kinases. Nat Rev Mol Cell Biol, 2016. 17(5): p. 280-292.
18. N. Li, A. Fassl, J. Chick, H. Inuzuka, X. Li, M.R. Mansour, L. Liu, H. Wang, B. King, S. Shaik, A. Gutierrez, A. Ordureau, T. Otto, T. Kreslavsky, L. Baitsch, L. Bury, C.A. Meyer, N. Ke, K.A. Mulry, M.J. Kluk, M. Roy, S. Kim, X. Zhang, Y. Geng, A. Zagozdzon, S. Jenkinson, R.E. Gale, D.C. Linch, J.J. Zhao, C.G. Mullighan, J.W. Harper, J.C. Aster, I. Aifantis, H. von Boehmer, S.P. Gygi, W. Wei, A.T. Look, and P. Sicinski, Cyclin C is a haploinsufficient tumour suppressor. Nat Cell Biol, 2014. 16(11): p. 1080-1091.
17. Y.J. Choi, B. Saez, L. Anders, P. Hydbring, J. Stefano, N.A. Bacon, C. Cook, I. Kalaszczynska, S. Signoretti, R.A. Young, D.T. Scadden, and P. Sicinski, D-cyclins repress apoptosis in hematopoietic cells by controlling death receptor Fas and its ligand FasL. Dev Cell, 2014. 30(3): p. 255-267.
16. Y.J. Choi, X. Li, P. Hydbring, T. Sanda, J. Stefano, A.L. Christie, S. Signoretti, A.T. Look, A.L. Kung, H. von Boehmer, and P. Sicinski, The requirement for cyclin D function in tumor maintenance. Cancer Cell, 2012. 22(4): p. 438-451.
15. L. Anders, N. Ke, P. Hydbring, Y.J. Choi, H.R. Widlund, J.M. Chick, H. Zhai, M. Vidal, S.P. Gygi, P. Braun, and P. Sicinski, A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells. Cancer Cell, 2011. 20(5): p. 620-634.
14. J. Odajima, Z.P. Wills, Y.M. Ndassa, M. Terunuma, K. Kretschmannova, T.Z. Deeb, Y. Geng, S. Gawrzak, I.M. Quadros, J. Newman, M. Das, M.E. Jecrois, Q. Yu, N. Li, F. Bienvenu, S.J. Moss, M.E. Greenberg, J.A. Marto, and P. Sicinski, Cyclin E constrains Cdk5 activity to regulate synaptic plasticity and memory formation. Dev Cell, 2011. 21(4): p. 655-668.
13. S. Jirawatnotai, Y. Hu, W. Michowski, J.E. Elias, L. Becks, F. Bienvenu, A. Zagozdzon, T. Goswami, Y.E. Wang, A.B. Clark, T.A. Kunkel, T. van Harn, B. Xia, M. Correll, J. Quackenbush, D.M. Livingston, S.P. Gygi, and P. Sicinski, A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers. Nature, 2011. 474(7350): p. 230-234.
12. F. Bienvenu, S. Jirawatnotai, J.E. Elias, C.A. Meyer, K. Mizeracka, A. Marson, G.M. Frampton, M.F. Cole, D.T. Odom, J. Odajima, Y. Geng, A. Zagozdzon, M. Jecrois, R.A. Young, X.S. Liu, C.L. Cepko, S.P. Gygi, and P. Sicinski, Transcriptional role of cyclin D1 in development revealed by a genetic-proteomic screen. Nature, 2010. 463(7279): p. 374-378.
11. I. Kalaszczynska, Y. Geng, T. Iino, S. Mizuno, Y. Choi, I. Kondratiuk, D.P. Silver, D.J. Wolgemuth, K. Akashi, and P. Sicinski, Cyclin A is redundant in fibroblasts but essential in hematopoietic and embryonic stem cells. Cell, 2009. 138(2): p. 352-365.
10. Y. Geng, Y.M. Lee, M. Welcker, J. Swanger, A. Zagozdzon, J.D. Winer, J.M. Roberts, P. Kaldis, B.E. Clurman, and P. Sicinski, Kinase-independent function of cyclin E. Mol Cell, 2007. 25(1): p. 127-139.
9. Q. Yu, E. Sicinska, Y. Geng, M. Ahnstrom, A. Zagozdzon, Y. Kong, H. Gardner, H. Kiyokawa, L.N. Harris, O. Stal, and P. Sicinski, Requirement for CDK4 kinase function in breast cancer. Cancer Cell, 2006. 9(1): p. 23-32.
8. K. Kozar, M.A. Ciemerych, V.I. Rebel, H. Shigematsu, A. Zagozdzon, E. Sicinska, Y. Geng, Q. Yu, S. Bhattacharya, R.T. Bronson, K. Akashi, and P. Sicinski, Mouse development and cell proliferation in the absence of D-cyclins. Cell, 2004. 118(4): p. 477-491.
7. E. Sicinska, I. Aifantis, L. Le Cam, W. Swat, C. Borowski, Q. Yu, A.A. Ferrando, S.D. Levin, Y. Geng, H. von Boehmer, and P. Sicinski, Requirement for cyclin D3 in lymphocyte development and T cell leukemias. Cancer Cell, 2003. 4(6): p. 451-461.
6. Y. Geng, Q. Yu, E. Sicinska, M. Das, J.E. Schneider, S. Bhattacharya, W.M. Rideout, R.T. Bronson, H. Gardner, and P. Sicinski, Cyclin E ablation in the mouse. Cell, 2003. 114(4): p. 431-443.
5. M.A. Ciemerych, A.M. Kenney, E. Sicinska, I. Kalaszczynska, R.T. Bronson, D.H. Rowitch, H. Gardner, and P. Sicinski, Development of mice expressing a single D-type cyclin. Genes Dev, 2002. 16(24): p. 3277-3289.
4. Y. Geng, Q. Yu, W. Whoriskey, F. Dick, K.Y. Tsai, H.L. Ford, D.K. Biswas, A.B. Pardee, B. Amati, T. Jacks, A. Richardson, N. Dyson, and P. Sicinski, Expression of cyclins E1 and E2 during mouse development and in neoplasia. Proc Natl Acad Sci U S A, 2001. 98(23): p. 13138-13143.
3. Q. Yu, Y. Geng, and P. Sicinski, Specific protection against breast cancers by cyclin D1 ablation. Nature, 2001. 411(6841): p. 1017-1021.
2. Y. Geng, Q. Yu, E. Sicinska, M. Das, R.T. Bronson, and P. Sicinski, Deletion of the p27Kip1 gene restores normal development in cyclin D1-deficient mice. Proc Natl Acad Sci U S A, 2001. 98(1): p. 194-199.
1. Y. Geng, W. Whoriskey, M.Y. Park, R.T. Bronson, R.H. Medema, T. Li, R.A. Weinberg, and P. Sicinski, Rescue of cyclin D1 deficiency by knockin cyclin E. Cell, 1999. 97(6): p. 767-777.